Ozempic, Mounjaro, Trulicity and Victoza are just several of the popular injectable medications known for producing weight-loss benefits unparalleled in other medications. Studies have demonstrated that patients’ weight loss varied between 10 and 30 pounds, depending on the specific medication. However, these medications, which are a part of the glucagon-like peptide-1 (GLP-1) receptor agonist family, were initially studied for their antidiabetic properties. It is thought that the mechanism by which these medications support weight loss is by slowing gastric emptying, allowing you to feel fuller longer and acting in the area of the brain responsible for regulating appetite as well as caloric intake. It is recommended that these medications be used in combination with proper diet and exercise to achieve maximum weight-loss benefits.
However, while the weight-loss benefits are clear, these medications are associated with a variety of side effects that should not be overlooked. The most common side effects associated with GLP-1 agonists include abdominal pain, constipation, diarrhea, nausea and vomiting. These side effects typically improve after continued use of the medication. Other side effects, which are less frequently observed but quite severe, include acute kidney injury, pancreatitis, gallbladder disease and medullary thyroid carcinoma. GLP-1 agonists are contraindicated in patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2).
Unfortunately, due to the popularity of these medications for their weight-loss properties, individuals with diabetes who had previously relied on these medications for the critical control of their blood sugar are now at risk of being unable to obtain their medication due to drug shortages.
While many individuals without diabetes are turning to these medications for a “quick” weight-loss fix, the associated side effects should not be ignored. These medications are often costly without insurance or prescription coverage. Additionally, as these medications are new to the drug market, the long-term weight-loss benefits and side effects currently remain unknown.
Before turning to these medications, a proper diet and exercise is always the first-line recommendation for weight loss and should be attempted before medications are considered. Speak with your physician or come by Parkview Pharmacy to find out more information about these medications.
