April 13, 2024
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Israel-21c—As the most severe Ebola epi­demic on record spreads through central Af­rica, infecting and killing hundreds of citizens and foreign aid workers, and raising the spect­er of outbreaks all over the world, an Israeli re­search team is working with survivors to de­velop antibodies against the lethal virus.

Dr. Leslie Lobel tells ISRAEL21c that he and fellow principal investigator Dr. Victoria Yav­elsky have spent many years studying native immunity to Ebola and another equally lethal Equatorial African virus, Marburg, at Ben-Guri­on University of the Negev’s Center for Emerg­ing Diseases, Tropical Diseases and AIDS.

Ebola, a hemorrhagic fever, is one of the deadliest viruses in the world. It kills up to 90 percent of its victims, while Marburg, another hemorrhagic fever, kills up to 88%.

Ebola can be spread through sweat and saliva and there is no vaccine or cure. In the latest outbreak, the worst ever, more than 670 people have died, including Americans. “Cur­rently we’ve tracked all Ebola and Marburg vi­rus survivors in Uganda, studied their immune responses to these viruses and identified sur­vivors with a strong immune response,” he says. “We take blood samples from them and isolate monoclonal antibodies that neutralize the virus in our lab here at Ben-Gurion.”

Yavelsky and Lobel’s therapeutic ap­proach was proven as a successful potential treatment by their colleagues in the US mili­tary, and at several other laboratories. This ap­proach is regarded as the most promising way to prevent Ebola and Marburg, and it could be available within five years.

Lobel travels to Africa about five times a year. “We have set up a base laboratory in En­tebbe, with our Ugandan colleagues, so that we can process human blood samples in un­der 12 hours from the time of collection, which is required for our work. After the samples are tested and deemed to be non-infectious, we ship them to Israel and our team here develops antibodies from the samples,” Lobel says.

With funding from the US National Insti­tutes of Health and other resources, Lobel’s lab is now getting ready to test its human mono­clonal antibodies in mice and non-human pri­mates. This will be performed abroad because no live virus research is permitted in Israel.

Five-year plan

“We have a five-year plan and I believe we could have proof of concept with human mon­oclonal antibodies in monkeys in three to five years,” Lobel predicts. “If we can prove it in two animal models we can eventually use it in hu­mans.”

He notes that the work being done at Ben- Gurion University is essential, since there are few studies on survivors of Ebola and there is no effective treatment thus far. “We’re quite ad­vanced in terms of studying the immune re­sponse in survivors in central Africa to develop a prophylactic and therapeutic [approach],” he tells ISRAEL21c.

The Israeli company Vecoy Nanomedi­cines is developing a biomedical technology platform that tricks a virus into “committing suicide,” a tactic that could neutralize viral threats like Ebola, hepatitis and HIV. However, Vecoy’s Dr. Eitan Eliram tells ISRAEL21c that Ve­coy has not yet found sufficient funding to go forward. Several other experimental vaccines and therapeutic approaches to Ebola and Mar­burg—mostly in the United States and Cana­da—are in various stages of development.

The current outbreak was noticed last February in Guinea, a country that is nor­mally outside the usual ecosystem for Ebo­la, according to Lobel. At the end of March, the US Centers for Disease Control sent a team to assist Guinea Ministry of Health and World Health Organization (WHO) in formulating an international response to the outbreak that is now affecting other Af­rican countries including Sierra Leone, Li­beria and Nigeria.

Poor compliance with health author­ities and many customary practices are thought responsible for the rapid spread of the virus. Because of international trav­el, however, the Ebola specter hangs over much of the world. Accordingly, WHO has been holding emergency coordina­tion meetings in several countries, and na­tions such as Liberia are sealing their bor­ders and establishing screening centers. The most affected areas are imposing quar­antines.

As of the end of July, Nancy Writebol and Dr. Ken Brantly, two American aid workers stationed at a Liberian hospital, tested positive for the Ebola virus.

By Abigail Klein Leichman

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